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ESSENTIAL ENZYME KINETICS

A TEXTBOOK FOR MOLECULAR LIFE SCIENTISTS

9780128218082 ::  ESSENTIAL ENZYME KINETICS
ISBN:

9780128218082

EditorialELSEVIER LTD
Edicion:
Páginas:330
Idioma:INGLES
P.V.P.: 95,95 € + 4% IVA = 99,79 €
Dto 5% Ahorras 4,99 €
Importe final iva incl. 94,80 €
EN PREPARACION OCTUBRE 2021

<P><I>ESSENTIAL ENZYME KINETICS: A TEXTBOOK FOR MOLECULAR LIFE SCIENTISTS</I> DESCRIBES THE THEORETICAL BASIS AND BEST-PRACTICE APPROACHES FOR USING INITIAL-RATE, FAST REACTION, AND KINETIC ISOTOPE EFFECT EXPERIMENTS TO DEFINE ENZYME CATALYSIS. BECAUSE A DETAILED KNOWLEDGE OF ENZYME TRANSITION-STATES IS THE MAIN DRIVER FOR THE RATIONAL DESIGN OF SLOW, TIGHT-BINDING INHIBITORS DESTINED TO BECOME TOMORROW'S SMALL-MOLECULE DRUGS, <I>ESSENTIAL ENZYME KINETICS</I> IS THE MUST-HAVE REFERENCE FOR CHEMISTS, BIOCHEMISTS, AND PHARMACOLOGISTS INTENT ON PURSUING CAREERS IN BIG PHARMA. GIVEN THE INTERDISCIPLINARY NATURE OF CONTEMPORARY DRUG DEVELOPMENT, THIS BOOK PROVIDES A LUCID SHORT-COURSE THAT WILL ALSO BENEFIT NONSPECIALISTS SEEKING TO UNDERSTAND THE SCOPE AND REACH OF MODERN ENZYME KINETICS. </P> <BR><BR><UL><LI>PROVIDES PRACTICAL INFORMATION ABOUT HOW TO WORK WITH ENZYMES AND DESIGN EXPERIMENTS TO IDENTIFY NEW INHIBITORS OR ACTIVATORS</LI><LI>INCLUDES DETAILED STEP-BY-STEP DERIVATIONS OF RATE EQUATIONS, SHOWING TRIED-AND-TRUE WAYS TO CONFIRM THAT THE EQUATIONS OBTAINED ARE CORRECT</LI><LI>ARRANGED FOR USE BOTH AS A DESK REFERENCE (WITH OVER 200 EQUATIONS AND MORE THAN 400 KEY REFERENCES) OR AS A TEXTBOOK (WITH 8-10 PROBLEMS/EXERCISES AT THE END OF EACH CHAPTER)</LI></UL>

<P>1. INTRODUCTION 2. BASIC CHEMICAL KINETICS 3. INITIAL-RATE KINETICS OF ONE-SUBSTRATE ENZYMES 4. MEASURING INITIAL VELOCITIES OF ENZYME-CATALYZED REACTIONS 5. MULTI-SUBSTRATE ENZYME KINETIC MECHANISMS 6. FAST KINETIC TECHNIQUES FOR PROBING ENZYME-CATALYZED REACTIONS 7. FACTORS AFFECTING ENZYME RATES 8. KINETIC ISOTOPE EFFECTS 9. INHIBITOR EFFECTS ON ENZYME-CATALYZED REACTIONS 10. ENZYME COOPERATIVITY 11. KINETICS OF FORCE-GENERATING ENZYMES</P>

BIOFISICA
BIOLOGIA CELULAR
BIOQUIMICA / BIOLOGIA MOLECULAR
FARMACOLOGIA
GERIATRIA
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