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COMPUTATIONAL SYSTEMS TOXICOLOGY

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9781493950034 ::  COMPUTATIONAL SYSTEMS TOXICOLOGY
ISBN:

9781493950034

Colección:METHODS IN PHARMACOLOGY AND TOXICOLOGY
EditorialSPRINGER NATURE
Edicion:
Páginas:430
Idioma:INGLES
Oferta estudiantes
P.V.P.: 109,99 € + 4% IVA = 114,39 €
Dto 5% Ahorras 5,72 €
Importe final iva incl. 108,67 €
PLAZO DE ENTREGA 15 DIAS
Otras versiones :

<P>THIS DETAILED VOLUME EXPLORES KEY STATE-OF-THE-ART COMPUTATIONAL APPLICATIONS THAT ARE CRUCIAL IN SYSTEMS TOXICOLOGY. THE RECENT TECHNOLOGICAL DEVELOPMENTS IN EXPERIMENTAL BIOLOGY AND MULTI-OMICS MEASUREMENTS THAT ENABLE SYSTEMS BIOLOGY AND SYSTEMS TOXICOLOGY CAN ONLY BE FULLY LEVERAGED BY THE APPLICATION OF A BROAD RANGE OF COMPUTATIONAL APPROACHES RANGING FROM DATA MANAGEMENT TO MATHEMATICAL MODELING. TAKING THIS INTO ACCOUNT, CHAPTERS IN THIS BOOK COVER DATA MANAGEMENT AND PROCESSING, DATA ANALYSIS, BIOLOGICAL NETWORK BUILDING AND ANALYSIS, AS WELL AS THE APPLICATION OF COMPUTATIONAL METHODS TO TOXICOLOGICAL ASSESSMENT.</P><P>WRITTEN FOR THE <I>METHODS IN PHARMACOLOGY AND TOXICOLOGY</I> SERIES, <I>COMPUTATIONAL SYSTEMS TOXICOLOGY</I> INCLUDES THE KIND OF KEY PRACTICAL ADVICE THAT WILL AID READERS IN FURTHERING OUR KNOWLEDGE OF TOXIC SUBSTANCES AND REACTIONS TO THEM.</P>

<P>1. THE ADVERSE OUTCOME PATHWAY: A CONCEPTUAL FRAMEWORK TO SUPPORT TOXICITY TESTING IN THE 21ST CENTURY</P><P>            EDWARD PERKINS, NATÀLIA GARCIA-REYERO, STEPHEN EDWARDS, CLEMENS WITTWEHR, DANIEL VILLENEUVE, DAVID LYONS, AND GERALD ANKLEY</P><P> </P><P>2. METABOLIC PATHWAY DATABASES: A WORD OF CAUTION</P><P>            MIRANDA D. STOBBE</P><P> </P><P>3. CAUSAL BIOLOGICAL NETWORK DATABASE: A COMPREHENSIVE PLATFORM OF CAUSAL BIOLOGICAL NETWORK MODELS FOCUSED ON THE PULMONARY AND VASCULAR SYSTEMS</P><P>            MARJA TALIKKA, STEPHANIE BOUE, AND WALTER K. SCHLAGE</P><P> </P><P>4. DATA SOURCES FOR SIGNATURE DISCOVERY IN TOXICOLOGY</P><P>            DRAGANA MITIC POTKRAJAC, BRANKA RAKIC, GORDANA APIC, AND ROBERT B. RUSSELL</P><P> </P><P>5. DATA MANAGEMENT AND PROCESSING IN TOXICOINFORMATICS: FROM CHEMICAL DATABASES TO AUTOMATIC EXTRACTION OF UNSTRUCTURED RESOURCES</P><P>            JULIANE FLUCK AND MARC ZIMMERMANN</P><P> </P><P>6. USING A CROWDSOURCING APPROACH FOR NETWORK VERIFICATION</P><P>            NATALIA BOUKHAROV AND JENNIFER S. PARK</P><P> </P><P>7. TOXICOLOGICAL ASSESSMENT VIA GENE NETWORK ANALYSIS</P><P>            SIMONA IACOBACCI, FRANCESCO GREGORETTI, GENNARO OLIVA, ROMAN POLISHCHUK, AND VINCENZO BELCASTRO</P><P> </P><P>8. WEAVING KNOWLEDGE INTO BIOLOGICAL PATHWAYS IN A COLLABORATIVE MANNER</P><P>            YUKIKO MATSUOKA, KAZUHIRO FUJITA, SAMIK GHOSH, AND HIROAKI KITANO</P><P> </P><P>9. PATHWAY ANALYSIS AND MACHINE LEARNING AS TOOLS IN SYSTEMS TOXICOLOGY</P><P>            ADI LAURENTIU TARCA</P><P> </P><P>10. QUANTIFYING THE BIOLOGICAL IMPACT OF ACTIVE SUBSTANCES USING CAUSAL NETWORK MODELS</P><P>            ALAIN SEWER, FLORIAN MARTIN, WALTER K. SCHLAGE, JULIA HOENG, AND MANUEL C. PEITSCH</P><P> </P><P>11. ANALYSIS OF PROTEOMIC DATA FOR TOXICOLOGICAL APPLICATIONS</P><P>            BJOERN TITZ, THOMAS SCHNEIDER, ASHRAF ELAMIN, FLORIAN MARTIN, SOPHIE DIJON, NIKOLAI V. IVANOV, JULIA HOENG, AND MANUEL C. PEITSCH</P><P> </P><P>12. XENOBIOTIC METABOLISM ACTIVATION AS A BIOMARKER OF CIGARETTE SMOKE EXPOSURE RESPONSE</P><P>            ANITA R. ISKANDAR</P><P> </P><P>13. HIGH-CONTENT SCREENING: UNDERSTANDING AND MANAGING MECHANISTIC DATA TO BETTER PREDICT TOXICITY</P><P>            PAUL WALKER, TIM SMITH, KERRY FROST, SARAH KELLY, AND IGNACIO GONZALEZ SUAREZ</P><P> </P><P>14. A SYSTEMS TOXICOLOGY APPROACH TO INVESTIGATING THE CARDIOVASCULAR EFFECTS OF CIGARETTE SMOKE AND ENVIRONMENTAL POLLUTANTS IN <I>APOE</I>-DEFICIENT MICE</P><P>            HÉCTOR DE LEÓN, STEPHANIE BOUE, MANUEL C. PEITSCH, AND JULIA HOENG</P><P> </P><P>15. COMPUTATIONAL DATA INTEGRATION IN TOXICOGENOMICS</P><P>            SIMONA CONSTANTINESCU, SHANA J. STURLA, GIANCARLO MARRA, BERND WOLLSCHEID, AND NIKO BEERENWINKEL</P><P> </P><P>16. AEROSOL DOSIMETRY MODELING USING COMPUTATIONAL FLUID DYNAMICS</P><P>            MARKUS NORDLUND AND ARKADIUSZ K. KUCZAJ</P>

BIOLOGIA
FARMACOLOGIA
TOXICOLOGIA
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