Libreria Herrero Books :: TDP-43 AND NEURODEGENERATION
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TDP-43 AND NEURODEGENERATION

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9780128200667 ::  TDP-43 AND NEURODEGENERATION
ISBN:

9780128200667

Publisher:ELSEVIER LTD
Edition:
Pages:270
Language:INGLES
P.V.P.: 132 € + 4% IVA = 137,28 €
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<P>AGGREGATES OF THE TAR DNA BINDING PROTEIN 43 (TDP-43), ARE HALLMARK FEATURES OF THE NEURODEGENERATIVE DISEASES AMYOTROPHIC LATERAL SCLEROSIS (ALS) AND FRONTOTEMPORAL DEMENTIA (FTD), WITH OVERLAPPING CLINICAL, GENETIC AND PATHOLOGICAL FEATURES. <I>TDP-43 AND NEURODEGENERATION: FROM BENCH TO BEDSIDE</I> SUMMARIZES NEW FINDINGS IN TDP-43 PATHOBIOLOGY AND PROTEINOPATHIES. THE BOOK SUMMARIZES TDP-43’S STRUCTURE, FUNCTION, BIOLOGY, MISFOLDING, AGGREGATION, PATHOGENESIS AND THERAPEUTICS. IT INCLUDES AUTOPHAGY-MEDIATED THERAPY, ROLE OF STRESS GRANULE, NOVEL GENETIC, CELL CULTURE-BASED MODELS, SYSTEMS BIOLOGY FOR PRECISION MEDICINE, DEVELOPMENT OF STEM CELLS AND MECHANISM-BASED THERAPIES THAT CAN TARGET ALS AND OTHER RELATED NEURODEGENERATIVE DISEASES. THIS BOOK IS WRITTEN FOR NEUROSCIENTISTS, NEUROLOGISTS, CLINICIANS, ADVANCED GRADUATE STUDENTS, DRUG DISCOVERY RESEARCHERS, AS WELL AS CELLULAR AND MOLECULAR BIOLOGISTS INVOLVED IN ALS, MOTOR NEURON DISEASE (MND) AND OTHER NEURODEGENERATIVE DISORDERS.</P> <BR><BR><UL> <LI>REVIEWS TDP-43 STRUCTURE, FOLDING, FUNCTION, AND PATHOLOGY</LI> <LI>IDENTIFIES TDP-43 ROLE IN ALS, FTP, AND OTHER NEURODEGENERATIVE DISEASES</LI> <LI>PRESENTS A SYSTEMS AND PRECISION BIOLOGY PERSPECTIVE OF TDP-43</LI> <LI>DISCUSSES THERAPEUTICS OF TDP-43 PROTEINOPATHIES</LI> <LI>TRANSLATES BENCH RESEARCH TO APPLICATION BEDSIDE</LI></UL>

1. TDP-43: PAST, PRESENT AND FUTURE<BR>2. STRUCTURAL STUDIES OF TDP-43<BR>3. TDP-43 MUTATIONS AND AMYOTROPHIC LATERAL SCLEROSIS<BR>4. POST TRANSLATIONAL MODIFICATIONS OF TDP-43<BR>5. TDP-43 AND AUTOPHAGY<BR>6. TDP-43 AND ALZHEIMER DISEASE<BR>7. TDP-43 AND STRESS GRANULES<BR>8. REPEAT DOMAINS IN TDP-43<BR>8. SYSTEMS BIOLOGY OF TDP-43<BR>9. ANIMAL MODELS OF TDP-43 IN ALS<BR>10. THERAPEUTIC MODULATIONS OF TDP-43

ANATOMY
BIOCHEMISTRY / MOLECULAR BIOLOGY
BIOLOGY
CYTOLOGY
LABORATORY MEDICINE
MEDICAL TERMINOLOGY
MOLECULAR & CELL BIOLOGY
NEUROLOGY
NEUROPHYSIOLOGY
NEUROSCIENCE / NEUROBIOLOGY
PUBLIC HEALTH
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