Libreria Herrero Books :: MECHANISMS OF CELL DEATH AND APPROACHES TO NEUROPROTECTION/DISEASE MODIFICATION IN PARKINSONS DISEA
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MECHANISMS OF CELL DEATH AND APPROACHES TO NEUROPROTECTION/DISEASE MODIFICATION IN PARKINSON’S DISEA

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9780323899437 ::  MECHANISMS OF CELL DEATH AND APPROACHES TO NEUROPROTECTION/DISEASE MODIFICATION IN PARKINSONS DISEA
ISBN:

9780323899437

Collection:INTERNATIONAL REVIEW OF MOVEMENT DISORDERS
Publisher:ELSEVIER LTD
Edition:
Pages:314
Language:INGLES
P.V.P.: 193 € + 4% IVA = 200,72 €
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<P><I>MECHANISMS OF CELL DEATH AND APPROACHES TO NEUROPROTECTION/DISEASE MODIFICATION IN PARKINSON’S DISEASE</I> EXPLORES THE RESULTS OF NUMEROUS STUDIES SURROUNDING  IN VITRO AND ANIMAL MODEL EVIDENCE THAT LOOKS AT THE IMPACT OF A-SYNUCLEINOPATHY ON NEURONAL DYSFUNCTION AND BEHAVIORAL IMPAIRMENTS, (II) HOW RESEARCH IN ANIMAL MODELS SUPPORTS THE DEVELOPMENT OF THERAPEUTIC STRATEGIES, AND (III) HOW FINDINGS IN ANIMAL MODELS MIGHT RELATE TO THE DISEASE PROCESS IN HUMANS. IN THIS BOOK, THE AUTHOR'S SHED LIGHT UPON THE COMPLEX SCENARIO OF THE MECHANISMS OF CELL DEATH AND APPROACHES TO NEUROPROTECTION/DISEASE MODIFICATION IN PD, BOTH IN VITRO TO IN VIVO.</P> <P>ALONG WITH DEGENERATION, THE PATHOLOGICAL HALLMARK OF PD IS THE PRESENCE OF INTRANEURONAL PROTEINACEOUS CYTOPLASMIC INCLUSIONS, NAMED LEWY BODIES (LB) THAT INVADE THE WHOLE NERVOUS SYSTEM AS THE DISEASE PROGRESSES. SEVERAL FUNDAMENTAL DISCOVERIES HAVE SHED LIGHT UPON THE IMPLICATION OF THE A-SYN PROTEIN IN THE PATHOGENESIS OF FAMILIAL AND SPORADIC FORMS OF PD. OTHER PROTEINS ALSO ACCUMULATE IN LB, BUT A-SYN IS A MAJOR PROTEIN COMPONENT OF THE PATHOLOGICAL LANDMARKS.</P> <BR><BR><UL> <LI>UPDATES ON THE LATEST RESEARCH SURROUNDING MECHANISMS OF CELL DEATH IN PARKINSON’S DISEASE</LI> <LI>INCLUDES IN VITRO AND IN VIVO MODELS OF SYNUCLEINOPATHY</LI> <LI>PRESENTS THERAPEUTIC STRATEGIES IN PARKINSON’S DISEASE</LI></UL>

<B> <P>1. ALPHA-SYNUCLEIN SPREADING MECHANISMS IN PARKINSON’S DISEASE: THE ROLE OF MEMBRANE RECEPTORS</P></B><I> <P>INÊS C. BRÁS AND TIAGO F. OUTEIRO</P> </I><B> <P>2. MODELING SYNUCLEINOPATHIES IN RODENTS</P></B><I> <P>ANNA BARBER JANER, ELINE VONCK AND VEERLE BAEKELANDT</P> </I><B> <P>3. SPREADING OF ALPHA-SYNUCLEIN PATHOLOGY FROM THE GUT TO THE BRAIN IN PARKINSON'S DISEASE</P></B><I> <P>BENJAMIN JEVANS AND DONATO A. DI MONTE</P> </I><B> <P>4. PINK1: MULTIPLE MECHANISMS OF NEUROPROTECTION</P></B><I> <P>BRITNEY N. LIZAMA, P. ANTHONY OTERO AND CHARLEEN T. CHU</P> </I><B> <P>5. MECHANISMS OF <I>VPS35</I>-MEDIATED NEURODEGENERATION IN PARKINSON'S DISEASE</P></B><I> <P>DORIAN SARGENT AND DARREN J. MOORE</P> </I><B> <P>6. MECHANISMS OF CELL DEATH AND APPROACHES TO NEUROPROTECTION/DISEASE MODIFICATION IN PARKINSON’S DISEASE</P></B><I> <P>ALEXIS MARTINEZ, MARIA JESUS CERNA, ROMINA GOZALVO AND CLAUDIO HETZ</P> </I><B> <P>7. IMMUNE RESPONSE DURING IDIOPATHIC PARKINSON'S DISEASE: FROM HUMANS TO ANIMAL MODELS</P></B><I> <P>SARA KONSTANTIN NISSEN, SARA A. FERREIRA, IDA KLÆSTRUP AND MARINA ROMERO-RAMOS</P></I>

NEUROLOGY
NEUROPHYSIOLOGY
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