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BIOMARKERS FOR IMMUNOTHERAPY OF CANCER

METHODS AND PROTOCOLS

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9781493997756 ::  BIOMARKERS FOR IMMUNOTHERAPY OF CANCER
ISBN:

9781493997756

Col·lecció:METHODS IN MOLECULAR BIOLOGY
Volum:2055
EditorialSPRINGER NATURE
Edició:
Idioma:INGLES
P.V.P.: 159,99 € + 4% IVA = 166,39 €
Dto 5% Estalvies 8,32 €
Import final iva incl. 158,07 €
Entrega en 15 dies
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<P>THIS BOOK PROVIDES THE IMMUNE ONCOLOGY (IO) COMMUNITY WITH A DEEPER UNDERSTANDING OF THE SCOPE OF THE BIOMARKER METHODS TO POTENTIALLY IMPROVE THE OUTCOME FROM IMMUNOTHERAPY. THE EDITORS SECURED THE INPUT FROM EXPERTS IN THE FIELD DEDICATED TO TRANSLATING SCIENTIFIC RESEARCH FROM BENCH TO BEDSIDE WAS SUBMITTED. THE BOOK PROVIDES NOT ONLY DETAILS ABOUT THE TECHNICAL, STANDARDIZATION AND INTERPRETATION ASPECTS OF THE METHODS BUT ALSO INTRODUCES THE READER TO THE BACKGROUND INFORMATION AND SCIENTIFIC JUSTIFICATION FOR SELECTED BIOMARKERS AND ASSAYS. WRITTEN IN THE HIGHLY SUCCESSFUL <I>METHODS IN MOLECULAR BIOLOGY </I>SERIES FORMAT, CHAPTERS INCLUDE INTRODUCTIONS TO THEIR RESPECTIVE TOPICS, LISTS OF THE NECESSARY MATERIALS AND REAGENTS, STEP-BY-STEP, READILY REPRODUCIBLE LABORATORY PROTOCOLS, AND TIPS ON TROUBLESHOOTING AND AVOIDING KNOWN PITFALLS.</P><BR>

PART I: SCIENTIFIC QUESTIONS AND THE STATUS OF INHIBITORY RECEPTORS FOR IMMUNOTHERAPY <P>1. STATUS OF IMMUNE-ONCOLOGY: CHALLENGES AND OPPORTUNITIES</P><P>ALESSANDRA CESANO, FRANCESCO M MARINCOLA, AND MAGDALENA THURIN<SUP></SUP></P><P>&NBSP;</P><P>2. IMMUNOLOGICAL TARGETS FOR IMMUNOTHERAPY: INHIBITORY T CELL RECEPTORS</P><P>DIWAKAR DAVAR AND HASSANE M. ZAROUR</P><P>&NBSP;</P><STRONG>PART II : MUTATIONAL AND GERMLINE PROFILING</STRONG><STRONG></STRONG> <P>3. MEASURING TUMOR MUTATIONAL BURDEN USING WHOLE EXOME SEQUENCING</P>TOMAS VILIMAS<P></P><P><I>&NBSP;</I></P><P>4. GERMLINE GENETICS IN IMMUNO-ONCOLOGY: FROM GENOME-WIDE TO TARGETED BIOMARKER STRATEGIES</P> <P>TOMAS KIRCHHOFF AND ROBERT FERGUSON</P><P>&NBSP;</P><P>5. DETECTION OF MICROSATELLITE INSTABILITY BIOMARKERS VIA NEXT-GENERATION SEQUENCING</P><P>RUSSELL BONNEVILLE, MELANIE A. KROOK, HUI-ZI CHEN, AMY SMITH, ERIC SAMORODNITSKY, MICHELE R. WING, JULIE W. REESER, AND SAMEEK ROYCHOWDHURY<SUP></SUP></P><P><I>&NBSP;</I></P><P>6. GENETIC INSTABILITY MARKERS IN CANCER </P><P>GIUSEPPE PALMIERI, MILENA CASULA, ANTONELLA MANCA, GRAZIA PALOMBA, MARIA CRISTINA SINI, VALENTINA DONEDDU , ANTONIO COSSU, AND MARIA COLOMBINO</P><P>&NBSP;</P><P>7. VALIDATION OF CIRCULATING TUMOR DNA ASSAYS FOR DETECTION OF METASTATIC MELANOMA</P><P>MAHRUKH M SYEDA, JENNIFER M. WIGGINS, BRODERICK CORLESS, CINDY SPITTLE, GEORGE KARLIN-NEUMANN, AND DAVID POLSKY</P><P>&NBSP;</P><P>8. TECHNIQUES ASSOCIATED WITH EXOSOME ISOLATION FOR BIOMARKER DEVELOPMENT – LIQUID BIOPSIES FOR OVARIAN CANCER DETECTION</P><P>SHAYNA SHARMA AND CARLOS SALOMON<SUP></SUP></P><P>&NBSP;</P>PART III: EPIGENETIC PROFILING <P>9. IDENTIFYING MICRORNA PATHWAY VARIANTS AS BIOMARKERS OF PATIENT SELECTION FOR IMMUNE THERAPY</P><P>JOANNE B. WEIDHAAS</P><P>&NBSP;</P><P>10. HISTONE MODIFICATIONS AS BIOMARKERS FOR IMMUNOTHERAPY</P><P>ERIN M. TAYLOR, BRIAN KOSS, LAUREN E. DAVIS, AND ALAN J. TACKETT</P>&NBSP; PART IV: FUNCTIONAL GENOMIC PROFILING <P>11. FUNCTIONAL GENOME PROFILING TO UNDERSTAND CANCER IMMUNE RESPONSIVENESS</P><P>&NBSP;ENA WANG, DAVIDE BEDOGNETTI, AND FRANCESCO M MARINCOLA<SUP></SUP></P><P>&NBSP;</P> 12. USING RNA-SEQUENCING TO CHARACTERIZE THE TUMOR MICROENVIRONMENT<P></P><P>SMITH CC, BIXBY LM, MILLER KL, SELITSKY SR, BORTONE DS, HOADLEY KA, VINCENT BG, AND SERODY JS</P><P>13. DEVELOPMENT OF GENE EXPRESSION BASED BIOMARKERS ON THE NCOUNTER® PLATFORM FOR IMMUNO-ONCOLOGY APPLICATIONS</P>SARAH WARREN, PATRICK DANAHER, AFSHIN MASHADI-HOSSEIN, LYNELL SKEWIS, BRETT WALLDEN, SEAN FERREE, AND ALESSANDRA CESANO<I></I><P></P><P>&NBSP;</P><P>14. THE CRISPR SYSTEM AND CANCER IMMUNOTHERAPY BIOMARKERS</P>VITALY BALAN AND JIANBIN WANG<P></P><P><I>&NBSP;&NBSP;&NBSP;&NBSP;&NBSP;&NBSP;&NBSP;&NBSP;&NBSP;&NBSP;&NBSP; </I></P>PART V: PHENOTYPING OF TUMOR AND IMMUNE CELLS <P>15. HLA CLASS I ANTIGEN PROCESSING MACHINERY DEFECTS IN CANCER CELLS - FREQUENCY, FUNCTIONAL SIGNIFICANCE AND CLINICAL RELEVANCE WITH SPECIAL EMPHASIS ON THEIR ROLE IN T CELL-BASED IMMUNOTHERAPY OF MALIGNANT DISEASE</P><P>BARBARA SELIGER AND SOLDANO FERRONE </P> <P>&NBSP;</P><P>16. HIGH-PARAMETER IMMUNE PROFILING WITH CYTOF</P><P>BITA SAHAF, ADEEB RAHMAN, HOLDEN T. MAECKER, AND SEAN BENDALL</P><P><I>&NBSP;</I></P><P>17. THE ADAPTOME AS BIOMARKER FOR ASSESSING CANCER IMMUNITY AND IMMUNOTHERAPY</P><P>JIAN HAN AND MICHAEL T. LOTZE</P><P><I>&NBSP;</I></P><P>18. SINGLE MOLECULE ARRAYS FOR ULTRASENSITIVE DETECTION OF&NBSP;BLOOD-BASED&NBSP;BIOMARKERS FOR IMMUNOTHERAPY&NBSP;</P><P>LIMOR COHEN, ALISSA KEEGAN, AND DAVID R WALT<SUP></SUP></P><P>&NBSP;</P><P>19. SINGLE-CELL MULTIPLEXED PROTEOMICS ON THE ISOLIGHT RESOLVES CELLULAR FUNCTIONAL HETEROGENEITY TO REVEAL CLINICAL RESPONSES OF CANCER PATIENTS TO IMMUNOTHERAPIES</P><P>DONG LIU, PATRICK PACZKOWSKI, SEAN MACKAY, COLIN NG, AND JING ZHOU</P><P>&NBSP;</P><P>20. METHODS TO DETECT IMMUNOGENIC CELL DEATH <I>IN VIVO</I></P><P>TAKAHIRO YAMAZAKI, AITZIBER BUQUÉ MARTINEZ, MARISSA RYBSTEIN, JONATHAN CHEN, AI SATO, AND LORENZO GALLUZZI</P><P>&NBSP;</P>PART VI: TISSUE IMAGING METHODS&NBSP; <P>21. OVERVIEW OF TISSUE IMAGING METHODS</P><P>SANJAY S. PATEL AND SCOTT J. RODIG</P><P>&NBSP;</P><P>22. MULTIPLEX IMMUNOFLUORESCENCE ASSAYS</P><P>ALEJANDRO FRANCISCO-CRUZ, EDWIN ROGER PARRA, MICHAEL T. TETZLAFF, AND IGNACIO I. WISTUBA, </P><P>&NBSP;</P><P>23. MULTIPLEXED IMMUNOHISTOCHEMICAL CONSECUTIVE STAINING ON SINGLE SLIDE (MICSSS): MULTIPLEXED CHROMOGENIC IHC ASSAY FOR HIGH-DIMENSIONAL TISSUE ANALYSIS</P><P>&NBSP;</P>GURAY AKTURK, ROBERT SWEENEY, ROMAIN REMARK<SUP> </SUP>, MIRIAM MERAD, AND SACHA GNJATIC<SUP></SUP> <P>&NBSP;</P>24 CYCLIC MULTIPLEXED-IMMUNOFLUORESCENCE (CMIF), A HIGHLY MULTIPLEXED METHOD FOR SINGLE-CELL ANALYSIS<P></P><P>JENNIFER ENG, GUILLAUME THIBAULT, SHIUH-WEN LUOH, JOE W. GRAY, YOUNG HWAN CHANG, AND KOEI CHIN</P><P>&NBSP;</P><P>25. HIGH-PLEX SPATIALLY RESOLVED RNA AND PROTEIN DETECTION USING DIGITAL SPATIAL PROFILING: A TECHNOLOGY DESIGNED FOR IMMUNO-ONCOLOGY BIOMARKER DISCOVERY AND TRANSLATIONAL RESEARCH</P><P>JOSEPH M. BEECHEM</P><P><I>&NBSP;</I></P>26. THE INSITUPLEX® STAINING METHOD FOR MULTIPLEXED IMMUNOFLUORESCENCE CELL PHENOTYPING AND SPATIAL PROFILING OF TUMOR FFPE SAMPLES<P></P><P>MAEL MANESSE, KATIR K. PATEL, SEAN R. DOWNING, ANDMARK BOBROW</P>&NBSP;<P></P>PART VII: MICROBIOME <P>27. MICROBIOME AS AN IMMUNOLOGICAL MODIFIER</P><P>MANOJ KUMAR, PARUL SINGH, SELVASANKAR MURUGESAN, MARIE VETIZOU, JOHN MCCULLOCH, JONATHAN H. BADGER, GIORGIO TRINCHIERI, AND SOUHAILA AL KHODOR<SUP></SUP></P><I>&NBSP;</I> PART VIII: SYSTEM BIOLOGY FOR MULTI-PLATFORM DATA INTEGRATION 28. SYSTEMS BIOLOGY FOR MULTI-PLATFORM DATA INTEGRATION - OVERVIEW <P>ELAD ZIV</P>&NBSP; <P>29. BIOINFORMATICS TOOLS AND RESOURCES FOR CANCER IMMUNOTHERAPY STUDY</P><P>ALIDA PALMISANO, JULIA KRUSHKAL, MING-CHUNG LI, JIANWEN FANG, DMITRIY SONKIN, GEORGE WRIGHT, LAURA YEE, YINGDONG ZHAO, LISA MCSHANE</P><P>&NBSP;</P><P>30. MULTIPLATFORM INTEGRATIVE ANALYSIS OF IMMUNOGENOMIC DATA FOR BIOMARKER DISCOVERY</P><P>VÉSTEINN THORSSON</P> <BR> PART IX: REGULATORY PERSPECTIVE <P>31. TRANSLATING IMMUNO-ONCOLOGY BIOMARKERS TO DIAGNOSTIC TESTS:&NBSP; A REGULATORY PERSPECTIVE</P><P>YOU LI, JANAKI VEERARAGHAVAN, AND REENA PHILIP</P><BR>

ANATOMIA PATOLOGICA
IMMUNOLOGIA
ONCOLOGIA
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